Systemic mastocytosis associated with chronic myelomonocytic leukemia and xanthogranuloma
نویسندگان
چکیده
A patient with a history of non-diagnostic bone marrow biopsies presented with a red to brown maculopapular rash on the back. Biopsies confirmed multiple xanthogranulomas as well as a mastocytosis. A consequently performed bone marrow biopsy verified a systemic mastocytosis and a chronic myelomonocytic leukemia (CMML) type I. HERE, WE DESCRIBE FOR THE FIRST TIME IN THE LITERATURE A PATIENT WITH THREE DISEASES OCCURRING SYNCHRONOUSLY: CMML, xanthogranulomas and systemic mastocytosis. Two of them at a time are known to be associated and may be indicative of a common progenitor cell.
منابع مشابه
Intertriginous maculopapular mastocytosis in a patient with acute myeloid leukemia
AHNMD: associated clonal hematologic none mast cell lineage disease CM: cutaneous mastocytosis CMML: chronic myelomonocytic leukemia MPCM: maculopapular cutaneous mastocytosis SM: systemic mastocytosis INTRODUCTION Maculopapular cutaneous mastocytosis (MPCM) is the clinical variant of cutaneous mastocytosis (CM) most frequently observed in adults, usually within the context of an indolent syste...
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متن کاملCase Report Systemic mastocytosis with associated clonal hematologic non-mast cell lineage disease (SM-AHNMD) involving chronic myelogenous leukemia with complex cytogenetics: A case report and literature review
Systemic mastocytosis with associated clonal hematologic non-mast cell lineage disease (SMAHNMD) is a subtype of systemic mastocytosis (SM) characterized by neoplastic proliferation of mast cells in association with a hematologic neoplasm defined by the World Health Organization (WHO) criteria. SM-AHNMD is more commonly associated with myeloid neoplasms such as, chronic myelomonocytic leukemia ...
متن کاملDetection of c-kit mutation Asp 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic leukaemia.
BACKGROUND/AIMS The occurrence of myeloid leukaemia in patients with systemic mastocytosis is a well recognised phenomenon. However, the pathophysiological basis of such a coevolution has not been clarified. Recent data have shown that the c-kit mutation Asp 816 to Val is detectable in neoplastic mast cells in most patients with systemic mastocytosis, including those who have associated haemato...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2012